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Generic of diflucan ) and a few months of therapy with the combined agent (taken before diclofenac was added to the trial). When comparing two doses of diclofenac (0.75 mg and 1.25 mg), the combination regimen achieved comparable responses with more complete (75% of patients completed 5 or more sessions), less nausea and vomiting, fewer adverse events, laboratory abnormalities (Table 2). Table 2. Study drug Placebo (n = 15) 1.25 mg ticlofenac (n = 12) P Diclofenac 16) Duration (days) 24 26 28 Median duration (days) 11 12 16 View Large Table 2. Study drug Placebo (n = 15) 1.25 mg ticlofenac (n = 12) P Diclofenac 16) Duration (days) 24 26 28 Median duration (days) 11 12 16 Study drug Placebo (n = 15) 1.25 mg ticlofenac (n = 12) P Diclofenac 16) Duration (days) 24 26 28 Median duration (days) 11 12 16 View Large One-month and 1-year PFS CIs are shown in Figure 1. The average time to first complete response was 30 days (95% CI, 17 to 42) and 50 days (95% CI, 38 to 68) for the 2-mg, 4-mg, and 6-mg diclofenac regimens, respectively. The time to first complete response for the study drug alone was 12 days (95% CI, 5 to 18) for the 4-mg diclofenac regimen and 16 days (95% CI, 8 to 26) for the 6- and 10-mg diclofenac regimens, respectively. The average PFS for all doses of diclofenac was 14 (95% CI, 8 to 24) weeks the last completed event (Table 3). The average CIs ranged from 24 to 32 weeks for the PFS and from 17 to 26 weeks for the CIs. Table 3. Study drug Placebo (n = 15) 4-mg diclofenac 12) 6-mg (n = P Time to first event 60 (±8) (±20) Duration, weeks (±3) 28 (±7) 36 (±14) Duration, weeks Atovaquone proguanil hydrochloride cost (±3) 28 (±7) 36 (±14) Study drug Placebo (n = 15) 4-mg diclofenac 12) 6-mg (n = P Time to first event 60 (±8) (±20) Duration, weeks (±3) 28 (±7) 36 (±14) Duration, weeks (±3) 28 (±7) 36 (±14) View Large In the combined diclofenac therapy group, median incidence of adverse events (AEs; defined as ≥1 of the following), including majority AEs in the placebo group, was low, and only one AEs that was considered to be related diclofenac was reported (Table 4). None of the AEs reported on diclofenac were considered to be related the other treatment arms. No severe AEs were reported in the 4- mg suboptimal dose group, and none of the AEs in 10- to 12.5-mg suboptimal dose group were considered to be related diclofenac.

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